Depending on your keyboard, you may need to check that the Function keys are enabled. There are a number of ways to enable the function keys.
Press and hold the Fn key and the F1 key together.
Press and hold the Ctrl key and the F1 key together.
Press and hold the Shift key and the F1 key together.
Google how to use the function keys for your specific keyboard.
Have your IT disable the Fn key through the System BIOS.
You can also try using an on-screen keyboard.
Open a Run command by pressing the Windows key and R on your keyboard.
Type osk and click OK.
Click FN to show the Function keys.
Click on the relevant item then click F1 or F5 from the on-screen keyboard.
If the on-screen keyboard does not work, you must reinstall the HandiSoft application from the latest version as the .chm files (help files) may be missing. See Access HandiSoft: How to download and install HandiSoft programs? for guidance.